مروری بر کاربرد نانوحامل‌های مختلف برای درمان انواع سرطان
Keywords:
سرطان, داروسانی هدفمند, نانوذرات, نانو ذرات طلا, نانو ذرات نقره, نانو ذرات پلیمریAbstract
در چند دهه گذشته تلاش و پژوهش‌های بسیاری در جهت توسعه نانوحامل‌ها برای دارورسانی و درمان سرطان انجام شده‌است. نانوحامل‌ها نشان دادند با توجه به اندازه، بار و خواص سطحی پتانسیل خوبی را برای تحویل داروهای ضد سرطان و درمان این بیماری شایع دارند. بر همین اساس، نانوذرات به عنوان حامل‌هایی برای تحویل داروهای ضد سرطان و جایگزینی به جای شیمی درمانی و درمان‌های پر خطر، بسیار قابل توجه هستند. نانوحامل‌ها اندازه‌های بسیار کوچکی دارند و در مقیاس نانو عمل میکنند، همین امر به آن‌ها ویژگی‌های خاصی در حوزه نگهداری دارو، حرکت در بافت‌ها و سلولها، اعمال دارو بر سلولهای سرطانی و خیلی ویژگی دیگر را میدهد. نتایج مشخص کرد که نانوذرات طلا و نقره، نانوذرات پلیمری و نانو ذرات اکسید آهن کاربرد بالقوه‌ای در حیطه دارورسانی هدفمند دارند. باتوجه به اهمیت استفاده از این نانوحامل‌ها و ضرورت استفاده از آن‌ها در درمان سرطان، هدف از این پژوهش مروری بر ویژگی‌ها و کاربردهای این نانوحامل‌ها در دارورسانی هدفمند و درمان انواع سرطان می‌باشد.
References
1. Barakat, F., et al., Designing and optimization of liposomal nano-carriers containing Nepeta persica extract and study of its cytotoxicity on the breast cancer cell line (MCF-7). The Journal of Shahid Sadoughi University of Medical Sciences, 2019. 27(2): p. 1202-1215.
2. Nokhodi, F., M.T. Goodarzi, and M. Nekoei, Polymer nanoparticles as a useful tool for controlled and targeted release of anticancer drugs: A review article. New Cellular and Molecular Biotechnology Journal, 2023. 13(50): p. 9-38.
3. Nokhodi, F., M.T. Goodarzi, and M. Nekoei, Polymer nanoparticles as a useful tool for controlled and targeted release of anticancer drugs: A review article. New Cellularand Molecular Biotechnology Journal, 2023. 13(50): p. 9-38.
4. Pourmadadi, M., et al., Polymeric nanoparticles as delivery vehicles for targeted delivery of chemotherapy drug fludarabine to treat hematological cancers. Inorganic Chemistry Communications, 2024: p. 112819.
5. Shahzamani, K., et al., A Study of Mechanism and Rate of PC12 Cancer Cell Destruction Induced by Lysine-Coated Gold Nanoparticle. Journal of Babol University of Medical Sciences, 2016. 18(8): p. 41-47.
6. Shamsi, F., Nanotechnology application in cancer treatment. Koomesh journal, 1398. 21(4): p. 579-589.
7. جانی تبار, س., ف. اسدی, and ح. بسطامی, جایگاه نانوذرات طلا در تشخیص و درمان. مجله زیست شناسی ایران, 2022. 6(11): p. 121-131.
8. Meng, Y.Q., et al., Recent trends in preparation and biomedical applications of iron oxide nanoparticles. Journal of Nanobiotechnology, 2024. 22(1): p. 24.
9. Karati, D., et al., A review on lipid-polymer hybrid nanocarriers in cancer. Journal of Drug Delivery Science and Technology, 2024: p. 105827.
10. Whitaker, K., Earlier diagnosis: the importance of cancer symptoms. The Lancet Oncology, 2020. 21(1): p. 6-8.
11. Tian, H., et al., Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies. Journal of hematology & oncology, 2022. 15(1): p. 132.
12. Bray, F., et al., Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2024. 74(3): p. 229-263.
13. Kamrani, A., et al., New immunotherapeutic approaches for cancer treatment. Pathology-Research and Practice, 2023. 248: p. 154632.
14. Niculescu, A.-G. and A.M. Grumezescu, Novel tumor-targeting nanoparticles for cancer treatment—A review. International Journal of Molecular Sciences, 2022. 23(9): p. 5253.
15. رضایی, م. and م. پارسافر, کاربرد نانوحامل ها در دارورسانی و درمان سرطان, in کنفرانس بین المللی پژوهش در علوم و تکنولوژی. 1395.
16. Huang, M., et al., Targeted drug delivery systems for curcumin in breast cancer therapy. International Journal of Nanomedicine, 2023: p. 4275-4311.
17. Rajendran, S., et al., Recent Development and Future Aspects: Nano-Based Drug Delivery System in Cancer Therapy. Topics in Catalysis, 2024. 67(1): p. 203-217.
18. بابایی, م. and ق. شیخ زاده, دارو رسانی هدفمند و درمان سرطان با نانو ذرات مغناطیسی, in اولین کنفرانس ملی نانو از سنتز تا صنعت. 1396.
19. Sun, L., et al., Smart nanoparticles for cancer therapy. Signal transduction and targeted therapy, 2023. 8(1): p. 418.
20. Chehelgerdi, M., et al., Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation. Molecular Cancer, 2023. 22(1): p. 169.
21. Karnwal, A., et al., Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications. ACS omega, 2024.
22. Panahi, Y., et al., Preparation, surface properties, and therapeutic applications of gold nanoparticles in biomedicine. Drug research, 2017. 11(02): p. 77-87.
23. Medici, S., et al. Gold nanoparticles and cancer: Detection, diagnosis and therapy. in Seminars in cancer biology. 2021. Elsevier.
24. Haume, K., et al., Gold nanoparticles for cancer radiotherapy: a review. Cancer nanotechnology, 2016. 7: p. 1-20.
25. Chugh, H., et al., Role of gold and silver nanoparticles in cancer nano-medicine. Artificial cells, nanomedicine, and biotechnology, 2018. 46(sup1): p. 1210-1220.
26. Silva, F., M.P. Cabral Campello, and A. Paulo, Radiolabeled gold nanoparticles for imaging and therapy of cancer. Materials, 2020. 14(1): p. 4.
27. Nicolae-Maranciuc, A., D. Chicea, and L.M. Chicea, Ag nanoparticles for biomedical applications—Synthesis and characterization—A review. International Journal of Molecular Sciences, 2022. 23(10): p. 5778.
28. Gomes, H.I., C.S. Martins, and J.A. Prior, Silver nanoparticles as carriers of anticancer drugs for efficient target treatment of cancer cells. Nanomaterials, 2021. 11(4): p. 964.
29. Goel, M., A. Sharma, and B. Sharma, Recent advances in biogenic silver nanoparticles for their biomedical applications. Sustainable Chemistry, 2023. 4(1): p. 61-94.
30. Takáč, P., et al., The role of silver nanoparticles in the diagnosis and treatment of cancer: Are there any perspectives for the future? Life, 2023. 13(2): p. 466.
31. De Matteis, V., et al., Silver nanoparticles: synthetic routes, in vitro toxicity and theranostic applications for cancer disease. Nanomaterials, 2018. 8(5): p. 319.
32. Kovács, D., et al., Cancer therapy by silver nanoparticles: fiction or reality? International journal of molecular sciences, 2022. 23(2): p. 839.
33. Soumya, R.S. and P.G. Hela, Nano silver based targeted drug delivery for treatment of cancer. Der Pharmacia Lettre, 2013. 5(4): p. 189-197.
34. Dristant, U., et al., An overview of polymeric nanoparticles-based drug delivery system in cancer treatment. Technology in cancer research & treatment, 2023. 22: p. 15330338231152083.
35. Gagliardi, A., et al., Biodegradable polymeric nanoparticles for drug delivery to solid tumors. Frontiers in pharmacology, 2021. 12: p. 601626.
36. Kumari, A., S.K. Yadav, and S.C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and surfaces B: biointerfaces, 2010. 75(1): p. 1-18.
37. Avramović, N., et al., Polymeric nanocarriers of drug delivery systems in cancer therapy. Pharmaceutics, 2020. 12(4): p. 298.
38. Tosi, G., et al., Potential use of polymeric nanoparticles for drug delivery across the blood-brain barrier. Current medicinal chemistry, 2013. 20(17): p. 2212-2225.
39. Chan, J.M., et al., Polymeric nanoparticles for drug delivery. Cancer nanotechnology: Methods and protocols, 2010: p. 163-175.
40. Sell, M., et al., Application of nanoparticles in cancer treatment: a concise review. Nanomaterials, 2023. 13(21): p. 2887.
41. Xie, M., et al., Surface Engineering of Magnetic Iron Oxide Nanoparticles for Breast Cancer Diagnostics and Drug Delivery. International Journal of Nanomedicine, 2024: p. 8437-8461.
42. Khizar, S., et al., Magnetic nanoparticles: Multifunctional tool for cancer therapy. Expert opinion on drug delivery, 2023. 20(2): p. 189-204.
43. Barahuie, F., et al., Sustained release of anticancer agent phytic acid from its chitosan-coated magnetic nanoparticles for drug-delivery system. Int J Nanomedicine, 2017. 12: p. 2361-2372.
44. Rezaei, M., A Review of Recent Advances in Iron Oxide Nanoparticles as a Magnetic Agent in Cancer Diagnosis and Treatment. Internal Medicine Today, 2022. 28(3): p. 280-299.
45. Rosen, J.E., et al., Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine: Nanotechnology, Biology and Medicine, 2012. 8(3): p. 275-290.
46. Palzer, J., et al., Iron oxide nanoparticle-based hyperthermia as a treatment option in various gastrointestinal malignancies. Nanomaterials, 2021. 11(11): p. 3013.
