Preparation of eugenol nanoemulsion by the spontaneous method
Keywords:
nanoemulsion, eugenol, essential oil, surfactant, particle size, spontaneous method, stabilityAbstract
Background: The present study aims to enhance the water solubility of eugenol through nanoemulsion formulation with spontaneous method and evaluate the particle size, surface load, thermodynamic stability, and drug release of the nanoemulsion.
Materials and Methods: Eugenol, oleic acid, and surfactant tween 80 were mixed using a vortex for 1 minute. Isopropyl alcohol was added as the aqueous phase and the mixture was polymerized using a magnet on a stirrer for 3 minutes. Thermodynamic stability studies were conducted on selected nanoemulsions.
Results: from the selected nanoemulsions, those with the smallest particle sizes, measuring (95,101,81,77) nm were identified. Additionally, all formulations exhibited a surface charge of 25 mv. eugenol nanoemulsion formulation demonstrated a reduced release rate compared to the solution state, indicating the potential for sustained drug release.
Conclusion: The spontaneous formation of nanoemulsion is regarded as a highly cost-effective approach that offers time and material savings, along with the production of stable nanoemulsions. this characteristic renders it particularly suitable for industrial applications necessitating high-volume production.
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