Application of Nanofibers in Drug Delivery
DOI:
https://doi.org/10.5281/zenodo.15641053Keywords:
Nanofibers, Drug delivery, Vitamins delivery, Biomedical applicationsAbstract
The growing interest in polymeric nanofibers for drug delivery systems is attributed to their exceptional micro and nanostructural characteristics, which include a high surface area, small pore size, and the ability to form three-dimensional structures. These properties enable the development of advanced materials with diverse applications in biomedicine. Electrospinning is recognized as a straightforward and cost-effective method for fabricating nanofibers. The electrospinning setup comprises a syringe with a nozzle, an electric field source, and a grounded target, along with a pump to facilitate the flow of polymer solutions. The electrospinning process is influenced by various parameters, categorized into solution, process, and ambient parameters, all of which significantly affect the morphology and characteristics of the resulting nanofibers.
Characterization methods for nanofibers include imaging techniques such as optical microscopy, scanning electron microscopy, and atomic force microscopy, as well as porosity measurement methods like mercury porosimetry. The chemical properties of nanofibers can be analyzed through Fourier transform infrared spectroscopy and nuclear magnetic resonance. The multifaceted applications of nanofibers in drug delivery encompass the delivery and detection of vitamins, DNA and siRNA delivery, growth factor delivery, and approaches for oral mucosal and peroral drug delivery, alongside their roles in biosensors, tissue engineering, regenerative medicine, and wound dressings. This comprehensive review focuses on recent advancements in nanofiber technology and its profound implications for enhancing clinical outcomes in drug delivery.
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