Investigating the Potential of Proso Millet (Panicum miliaceum L.) as a Functional Food
DOI:
https://doi.org/10.5281/zenodo.19678637کلمات کلیدی:
Proso millet, Functional foods, Bioactive compounds, Food securityچکیده
Proso millet (Panicum miliaceum L.) is among the earliest domesticated millet species and serves as a vital staple food for populations living in arid and semi-arid regions worldwide. This review highlights its rich nutritional profile, including high-quality proteins rich in essential amino acids (such as isoleucine, methionine, and leucine), essential fatty acids (notably linoleic acid, an omega-6 fatty acid), and antioxidant compounds such as phenolic acids and glycosylated flavonoids. Compared to common cereals like rice and wheat, proso millet offers higher protein quality and a richer profile of bioactive compounds, highlighting its potential as a valuable functional food ingredient. Beyond its nutritional value, proso millet exhibits multiple health-promoting properties, including antioxidant, anti-diabetic, anti-cancer, antiproliferative, anti-liver injury, and anti-obesity effects. Its gluten-free nature also makes it suitable for individuals with celiac disease. It may have significant benefits for maintaining the gastrointestinal, respiratory, and cardiovascular systems, as well as hair health. Furthermore, advanced processing techniques, including physiochemical and bioprocessing techniques (such as fermentation and germination), thermal processing, and non-thermal technologies, have shown promise in enhancing its nutritive and antioxidant compounds while reducing antinutritional factors. In addition, multidisciplinary approaches, including genomics and bioinformatics, play a crucial role in advancing millet improvement and achieving nutritional security. Despite its functional potential, proso millet remains underutilized commercially due to technical limitations, including the short shelf life of millet flour, the degradation of micronutrients, total proteins, and dietary fiber during dehulling, and a lack of studies focused on industrial scaling. Overall, this review highlights proso millet as a sustainable, health-promoting crop that aligns with global efforts to combat malnutrition and chronic diseases while enhancing food system resilience to climate change.
دانلودها
مراجع
1. Alzahrani, N.S., Alshammari, G.M., El-Ansary, A., Yagoub, A.E.A., Amina, M., Saleh, A., & Yahya, M.A. (2022). Anti-Hyperlipidemia, Hypoglycemic, and Hepatoprotective Impacts of Pearl Millet (Pennisetum glaucum L.) Grains and Their Ethanol Extract on Rats Fed a High-Fat Diet. Nutrients, 14(9), 1791. https://doi.org/10.3390/nu14091791
2. Amadou, I., Gounga, M.E., & Le, G. (2013). Millets: Nutritional Composition, Some Health Benefits and Processing — A Review. Emirates Journal of Food and Agriculture, 25 (7), 501-508. DOI:10.9755/EJFA.V25I7.12045
3. Anitha, S., Tsusaka, T.W., Botha, R., Givens, D.I., Rajendran, A., Parasannanavar, D.J., Subramaniam, K., Bhandari, R.K., & Kane-Potaka, J. (2024). Impact of Regular Consumption of Millets on Fasting and Post-Prandial Blood Glucose Level: A Systematic Review and Meta-Analysis. Frontiers in Sustainable Food Systems, 7:1226474. https://doi.org/10.3389/fsufs.2023.1226474
4. Balyatanda, S.B., Gowda, N.A., Subbiah, J., Chakraborty, S., Prasad, P.V., & Siliveru, K. (2024). Physiochemical, Bio, Thermal, and Non-Thermal Processing of Major and Minor Millets: A Comprehensive Review on Antinutritional and Antioxidant Properties. Foods, 13, 3684. https://doi.org/10.3390/foods13223684
5. C. A., R., Lakshmeesha, R., Yasaswini., P., Divya, C., & Ashoka, S. (2024). Millets: A Scientific Perspective on Their Nutritional and Health Relevance. Journal of Scientific Research and Reports, 30(5), 494–509. https://doi.org/10.9734/jsrr/2024/v30i51966
6. Chellappan, B.V., & Peramaiyan, R. (2024). Unleashing the Potential of Millets: A Comprehensive Review of Its Nutritional, Therapeutic, and Genomic Attributes. Journal of Biological Research, 97:1231. DOI:10.4081/jbr.2024.12131
7. Choi, N., Kim, K. C., Jeong, P. Y., & Kim, B. (2023). Effects of the Complex of Panicum miliaceum Extract and Triticum aestivum Extract on Hair Condition. Nutrients, 15(20), 4411. DOI: 10.3390/nu15204411
8. Deng, X., Liang, J., Wang, L., Niu, L., Xiao, J., Guo, Q., Liu, X., & Xiao, C. (2023). Whole Grain Proso Millet (Panicum miliaceum L.) Attenuates Hyperglycemia in Type 2 Diabetic Mice: Involvement of miRNA Profile. Journal of agricultural and food chemistry, 71(24), 9324–9336. https://doi.org/10.1021/acs.jafc.2c08184
9. El-Hashash, E.F., Al-Habeeb, A.M., Bakri, H., & Majjami, A.Y. (2023). A Comprehensive Review of Pearl and Small Millets: Taxonomy, Production, Breeding and Future Prospects in Saudi Arabia. Asian Journal of Research in Crop Science, 8(4), 151-166. DOI:10.9734/ajrcs/2023/v8i4196
10. Jevcsák, S., & Sipos, P. (2016). Sorghum and Millet as Alternative Grains in Nutrition. Acta Agraria Debreceniensis, 69, 91-95. https://doi.org/10.34101/actaagrar/69/1795
11. Jun, D.Y., Han, C.R., & Kim, Y.H. (2023). Apoptotic Effect of Proso Millet Grains on Human Breast Cancer MDA-MB-231Cells Is Exerted by Activation of BAK and BAX, and Mitochondrial Damage-mediated Caspase Cascade Activation. Journal of Life Science, 33(1), 15–24. https://doi.org/10.5352/JLS.2023.33.1.15
12. Lee, E., Seo, H.D., Kim, D., Park, S.H., Kim, S.R., Hyun, C., Hahm, J.H., Ha, T.Y., Ahn, J., & Jung, C.H. (2023). Millet Seed Oil Activates β-Catenin Signaling and Promotes Hair Growth. Frontiers in pharmacology, 14, 1172084. https://doi.org/10.3389/fphar.2023.1172084
13. Lima, J.F., Días, M.I., Pereira, C., Ivanov, M., Soković, M.D., Steinmacher, N.C., Ferreira, I.C., & Barros, L. (2021). Characterization of Nonconventional Food Plants Seeds Guizotia abyssinica (L.f.) Cass., Panicum miliaceum L., and Phalaris canariensis L. for Application in the Bakery Industry. Agronomy, 11(9), 1873. https://doi.org/10.3390/agronomy11091873
14. Manwaring, H.R., Bligh, H., & Yadav, R.S. (2016). The Challenges and Opportunities Associated with Biofortification of Pearl Millet (Pennisetum glaucum) with Elevated Levels of Grain Iron and Zinc. Frontiers in Plant Science, 7:1944. DOI:10.3389/fpls.2016.01944
15. Nayak, N., Bhujle, R.R., Nanje-Gowda, N., Chakraborty, S., Siliviru, K., Subbiah, J., & Brennan, C.S. (2024). Advances in the Novel and Green-Assisted Techniques for Extraction of Bioactive Compounds from Millets: A Comprehensive Review. Heliyon, 10. DOI:10.1016/j.heliyon.2024.e30921
16. Park, K.O., Ito, Y., Nagasawa, T., Choi, M.R., & Nishizawa, N. (2008). Effects of Dietary Korean Proso-Millet Protein on Plasma Adiponectin, HDL Cholesterol, Insulin Levels, and Gene Expression in Obese Type 2 Diabetic Mice. Bioscience, biotechnology, and biochemistry, 72(11), 2918–2925. https://doi.org/10.1271/bbb.80395
17. Park, M. Y., Jang, H. H., Kim, J. B., Yoon, H. N., Lee, J. Y., Lee, Y. M., Kim, J. H., & Park, D. S. (2011). Hog Millet (Panicum miliaceum L.)-Supplemented Diet Ameliorates Hyperlipidemia and Hepatic Lipid Accumulation in C57BL/6J-ob/ob Mice. Nutrition research and practice, 5(6), 511–519. DOI: 10.4162/nrp.2011.5.6.511
18. Ravi, J.L., & Rana, S. S. (2024). Maximizing the Nutritional Benefits and Prolonging the Shelf Life of Millets through Effective Processing Techniques: A Review. ACS omega, 9(37), 38327–38347. https://doi.org/10.1021/acsomega.4c03466
19. Ren, J., Ma, C., Li, M., Dang, Y., Yu, X., & Du, S. (2023). Physicochemical, Structural Structural and Functional Properties of Non-Waxy and Waxy Proso Millet Protein. Foods, 12(5), 1116. https://doi.org/10.3390/foods12051116
20. Sabuz, A. A., Rana, M. R., Ahmed, T., Molla, M. M., Islam, N., Khan, H. H., Chowdhury, G. F., Zhao, Q., & Shen, Q. (2023). Health-Promoting Potential of Millet: A Review. Separations, 10(2), 80. https://doi.org/10.3390/separations10020080
21. Saqib, F., Al-Huqail, A. A., Asma, M., Chicea, L., Hogea, M., Irimie, M., & Gavris, C. (2022). Dose-dependent Spasmolytic, Bronchodilator, and Hypotensive Activities of Panicum miliaceum L. Dose-response: a publication of International Hormesis Society, 20(1), 15593258221079592. DOI: 10.1177/15593258221079592
22. Satyavathi, C.T., Ambawat, S., Khandelwal, V., & Srivastava, R.K. (2021). Pearl Millet: A Climate-Resilient Nutricereal for Mitigating Hidden Hunger and Provide Nutritional Security. Frontiers in Plant Science, 12:659938. DOI:10.3389/fpls.2021.659938
23. Sekhar, M., Sagar, A., Khan, W., & Patel, J. (2021). Millets as Nutre Cereals. International Journal of Advances in Agricultural Science and Technology, 8(9), 163-174. DOI:10.47856/ijaast.2021.v08i9.018
24. Sharma, D., Jamra, G., Singh, U.M., Sood, S., & Kumar, A. (2017). Calcium Biofortification: Three Pronged Molecular Approaches for Dissecting Complex Trait of Calcium Nutrition in Finger Millet (Eleusine coracana) for Devising Strategies of Enrichment of Food Crops. Frontiers in Plant Science, 7:2028. DOI:10.3389/fpls.2016.02028
25. Shen, R., Ma, Y., Jiang, L., Dong, J., Zhu, Y., & Ren, G. (2018). Chemical Composition, Antioxidant, and Antiproliferative Activities of Nine Chinese Proso Millet Varieties. Food and Agricultural Immunology, 29, 625 -637. https://doi.org/10.1080/09540105.2018.1428283
26. Shi, J., Shan, S., Li, H., Song, G., & Li, Z. (2017). Anti-Inflammatory Effects of Millet Bran Derived-Bound Polyphenols in LPS-Induced HT-29 Cell via ROS/miR-149/Akt/NF-κB Signaling Pathway. Oncotarget, 8(43), 74582–74594. https://doi.org/10.18632/oncotarget.20216
27. Singh, A., Kumar, M., & Shamim, M. (2020). Importance of Minor Millets (Nutri Cereals) for Nutrition Purpose in Present Scenario. International Journal of Chemical Studies, 8(1), 3109-3113. DOI: 10.22271/chemi.2020.v8.i1au.9226
28. Wei, S., Cheng, D., Yu, H., Wang, X., Song, S., Wang, C. (2018). Millet-Enriched Diets Attenuate High Salt-Induced Hypertension and Myocardial Damage in Male Rats. Journal of Functional Foods, 44, 304-312. https://doi.org/10.1016/j.jff.2018.03.028
29. Xiang, J., Yuan, Y., Du, L., Zhang, Y., Li, C., & Beta, T. (2023). Modification on Phenolic Profiles and Enhancement of Antioxidant Activity of Proso Millets During Germination. Food chemistry: X, 18, 100628. https://doi.org/10.1016/j.fochx.2023.100628
30. Zhang, L., Liu, R.H., & Niu, W. (2014). Phytochemical and Antiproliferative Activity of Proso Millet. PLoS ONE, 9(8): e104058. DOI: 10.1371/journal.pone.0104058