Advancements in 3D Printing Technologies: Nanoparticle, Tissue Engineering and Challenges- A Review
Keywords:
Additive Manufacturing (AM), 3D Printing, Polymer Composites, Nanoparticles, Tissue Engineering, Selective Laser Sintering (SLS)Abstract
3D printing, also known as additive manufacturing (AM), is a transformative technology that constructs three-dimensional objects from digital models by adding material layer by layer. Its versatility in material usage, ranging from polymers and metals to ceramics and composites, has revolutionized industries like aerospace, automotive, and biomedical engineering. This technology allows for the fabrication of complex geometries and customized designs while minimizing material waste. Despite its advantages, 3D printing faces challenges such as material limitations, optimization of parameters, and the need for multi-material processing. Recent advancements include hybrid printing techniques, enhancing the mechanical properties and functionality of printed objects. Additionally, the integration of nanoparticles into biopolymers is driving innovation in tissue engineering, improving scaffold strength, bioactivity, and tissue regeneration. As research continues to overcome existing challenges, 3D printing is expected to expand its industrial applications and evolve into an essential tool for modern manufacturing.
References
[1] T.D. Ngo, A. Kashani, G. Imbalzano, K.T.Q. Nguyen, D. Hui, Additive manufacturing (3D printing): a review of materials, methods,applications and challenges, Compos. B Eng. 143 (2018) 172–196.
[2] S.D. Ligon, R. Liska, J. Stampfl, M. Gurr, R. Mülhaupt, Polymers for 3D printing and customized additive manufacturing, Chem. Rev. 117 (15) (2017) 10212–10290.
[3] K. Sun, T.S. Wei, B.Y. Ahn, J.Y. Seo, S.J. Dillon, J.A. Lewis, 3D printing of interdigitated Li-ion microbattery architectures, Adv. Mater. 25 (33) (2013) 4539–4543.
[4] C So Ladd, J.H. Muth, M.D. J Dickey, 3D printing of free standing liquid metal microstructures, Adv. Mater. 25 (36) (2013) 5081–5085.
[5] U. Scheithauer, T. Slawik, E. Schwarzer, H.J. Richter, T. Moritz, A. Michaelis, Additive manufacturing of metal-ceramic-composites by Thermoplastic3D-printing (3DTP), Journal of Ceramic Science and Technology 6 (2) (2015) 125–131.
[6] S. Hwang, E.I. Reyes, K.S. Moon, R.C. Rumpf, N.S. Kim, Thermo-mechanical characterization of metal/polymer composite filaments and printing parameter study for fused deposition modeling in the 3D printing process, J. Electron. Mater. 44 (3) (2015) 771–777.
[7] J.D. Carrico, N.W. Traeden, M. Aureli, K.K. Leang, Fused filament 3D printing of ionic polymer-metal composites (IPMCs), Smart Mater. Struct. 24 (12) (2015) 125021.
[8] L. Michal, K. Michal, S. Malgorzata, Fast track integration of computational methods with experiments in small wind turbine development, Energies 12 (9) (2019) 1625.
[9] P. Anupama, G. Rachel, Exploration of 3D printing to create zerowaste sustainable fashion notions and jewelry, Fashion and Textiles 5 (1) (2018) 1–18.
[10] K. Altaf, J.A. Qayyum, A.M.A. Rani, F. Ahmad, P.S.M. Megat-Yusoff, M. Baharom, A.R.A. Aziz, M. Jahanzaib, R.M. German, Performance analysis of enhanced 3D printed polymer molds for metal injection molding process, Metals 8 (6) (2018) 433.
[11] C.N. Kellu, A.T. Miller, S.J. Hollister, R.E. Guldberg, K. Gall, Design and structurefunction characterization of 3D printed synthetic porous biomaterials for tissue engineering, Adv. Healthc. Mater. 7 (7) (2018) 1701095.
[12] Y.W.D. Tay, B. Panda, S.C. Paul, N.A.N. Mohamed, M.J. Tan, K.F. Leong, 3D printing trends in building and construction industry: a review, Virtual Phys. Prototyp. 12 (3) (2017) 261–276.
[13] Wang, C., Huang, W., Zhou, Y., He, L., He, Z., Chen, Z., ... & Wang, M. (2020). 3D printing of bone tissue engineering scaffolds. Bioactive materials, 5(1), 82-91.
[14] O. Ivanova, C. Williams, T. Campbell, Additive manufacturing (AM) and nanotechnology: promises and challenges, Rapid Prototype J. 19 (5) (2013) 353_364.
[15] J. Xiong, et al., Advanced micro-lattice materials, Adv. Eng. Mater. 17 (9) (2015) 1253_1264.
[16] Saroia, J., Wang, Y., Wei, Q., Lei, M., Li, X., Guo, Y., & Zhang, K. (2020). A review on 3D printed matrix polymer composites: its potential and future challenges. The international journal of advanced manufacturing technology, 106, 1695-1721.
[17] Singh, S., Ramakrishna, S., & Berto, F. (2020). 3D Printing of polymer composites: A short review. Material Design & Processing Communications, 2(2), e97.
[18] Wang, X., Jiang, M., Zhou, Z., Gou, J., & Hui, D. (2017). 3D printing of polymer matrix composites: A review and prospective. Composites Part B: Engineering, 110, 442-458.
[19] Sood AK, Ohdar R, Mahapatra S. Parametric appraisal of mechanical property of fused deposition modelling processed parts. Mater Des 2010;31(1): 287e95.
[20] Parandoush P, Lin D. A review on additive manufacturing of polymer‐fiber composites. Compos Struct. 2017 Dec 15;182:36‐53.
[21] Singh S, Ramakrishna S, Singh R. Material issues in additive manufacturing: a review. J Manuf Process. 2017 Jan 1;25:185‐200.
[22] H.N. Chia, B.M. Wu, Recent advances in 3D printing of biomaterials, J Biol Eng 9 (2015) 4.
[23] Mohamed OA, Masood SH, Bhowmik JL. Optimization of fused deposition modeling process parameters: a review of current research and future prospects. Adv Manuf. 2015 Mar 1;3(1):42‐53.
[24] Sanatgar RH, Campagne C, Nierstrasz V. Investigation of the adhesion properties of direct 3D printing of polymers and nanocomposites on textiles: effect of FDM printing process parameters. Appl Surf Sci. 2017 May 1;403:551‐563.
[25] Rosli NA, Hasan R, Alkahari MR, Tokoroyama T. Effect of process parameters on the geometrical quality of ABS polymer lattice structure. InProceedings of SAKURA Symposium on Mechanical Science and Engineering 2017 2017 Nov 10 (pp. 3‐5). Centre for Advanced Research on Energy.
[26] Mohamed OA,Masood SH, Bhowmik JL (2015) Optimization of fused depositionmodeling process parameters: a review of current research and future prospects. Adv Manuf 3(1):42–53
[27] Majeed A, Lv J, Peng T (2019) A framework for big data driven process analysis and optimization for additive manufacturing.Rapid Prototyp J 25(2):308–321.
[28] Parandoush P, Lin D (2017) A review on additive manufacturing of polymer-fiber composites. Compos Struct 182:36–53
[29] Wang X, Jiang M, Zhou Z, Gou J, Hui D (2017) 3D printing of polymer matrix composites: A review and prospective. Compos
Part B: Eng 110:442–458
[30] W. Wu, P. Geng, G. Li, D. Zhao, H. Zhang, J. Zhao, Influence of Layer Thickness and Raster Angle on the Mechanical Properties of 3D-Printed PEEK and a Comparative Mechanical Study between PEEK and ABS, Materials (Basel) 8(9) (2015) 5834-5846.
[31] A. Gremare, V. Guduric, R. Bareille, V. Heroguez, S. Latour, N. L'Heureux, J.C. Fricain, S. Catros, D. Le Nihouannen, Characterization of printed PLA scaffolds for bone tissue engineering, J Biomed Mater Res A 106(4) (2018) 887-894.
[32] Caulfield B, McHugh PE, Lohfeld S. Dependence of mechanical properties of polyamide components on build parameters in the SLS process. J Mater Process Technol. 2007 Feb 2;182(1–3):477‐488.
[33] Williams JD, Deckard CR. Advances in modeling the effects of selected parameters on the SLS process. Rapid Prototyp J. 1998 Jun 1;4(2):90‐100.
[34] Gu D, Meiners W, Wissenbach K, Poprawe R. Laser additive manufacturing of metallic components: materials, processes and mechanisms. Int Mater Rev 2012;57(3):133e64.
[35] Gibson I, Shi D. Material properties and fabrication parameters in selective laser sintering process. Rapid Prototyp J 1997;3(4):129e36.
[36] Goodridge R, Shofner M, Hague R, McClelland M, Schlea M, Johnson R, Tuck C. Processing of a Polyamide-12/carbon nanofibre composite by laser sintering. Polym Test 2011;30(1):94e100.
[37] Prakash KS, Nancharaih T, Rao VS. Additive manufacturing techniques in manufacturing—an overview. Mater Today Proc. 2018 Jan 1;5(2):3873‐3882.
[38] Wong KV, Hernandez A. A review of additive manufacturing. ISRN Mech Eng. 2012 Aug;16:2012.
[39] Brooks G, Kinsley K, Owens T (2014) 3D printing as a consumer technology business model. Int J Manag Inf Syst (Online) 18(4): 271
[40] Chia HN, Wu BM (2015) Recent advances in 3D printing of biomaterials. J Biol Eng 9(1):4
[41] Kim K, ZhuW, Qu X, Aaronson C, McCallWR, Chen S, Sirbuly DJ (2014) 3D optical printing of piezoelectric nanoparticle– polymer composite materials. ACS Nano 8(10):9799–9806
[42] Gu D, Meiners W, Wissenbach K, Poprawe R (2012) Laser additive manufacturing of metallic components: materials, processes and mechanisms. Int Mater Rev 57(3):133–164
[43] Zhang, L., Yang, G., Johnson, B. N., & Jia, X. (2019). Three-dimensional (3D) printed scaffold and material selection for bone repair. Acta biomaterialia, 84, 16-33.
[44] Brandhoff L, van den Driesche S, Lucklum F, Vellekoop MJ. Creation of hydrophilic microfluidic devices for biomedical application through stereolithography. InBio‐MEMS and Medical Microdevices II 2015 Jun 1 (Vol. 9518, p. 95180D). International Society for Optics and Photonics
[45] Stansbury JW, Idacavage MJ. 3D printing with polymers: Challenges among expanding options and opportunities. Dent Mater. 2016 Jan 1;32(1):54‐64.
[46] Maas J, Liu B, Hajela S, Huang Y, Gong X, Chappell WJ. Laser‐based layer‐by‐layer polymer stereolithography for high frequency applications. Proc IEEE. 2017 Apr;105(4):645‐654.
[47] Dikshit, V., Goh, G. D., Nagalingam, A. P., Goh, G. L., & Yeong, W. Y. (2020). Recent progress in 3D printing of fiber-reinforced composite and nanocomposites. Fiber-Reinforced Nanocomposites: Fundamentals and Applications, 371-394.
[48] Olakanmi EO, Cochrane RF, Dalgarno KW. Densification mechanism and microstructural evolution in selective laser sintering of Al–12Si powders. J Mater Process Technol. 2011 Jan 1;211(1):113‐121.
[49] D. Klosterman, et al., Direct fabrication of ceramics and composites through laminated object manufacturing (LOM), Mater. Process. Affordab. Keys Future (1998) 693_705.
[50] Kumar S, Kruth JP. Composites by rapid prototyping technology. Mater Des. 2010 Feb 1;31(2):850‐856.
[51] Calvert P. Inkjet printing for materials and devices. Chem Mater. 2001 Oct 15;13(10):3299‐3305.
[52] Calvert P, Crockett R. Chemical solid free‐form fabrication: making shapes without molds. Chem Mater. 1997 Mar 18;9(3):650‐663.
[53] Kawase T, Shimoda T, Newsome C, Sirringhaus H, Friend RH. Inkjet printing of polymer thin film transistors. Thin Solid Films. 2003 Aug 22;438:279‐287.
[54] Li J, Ye F, Vaziri S, Muhammed M, Lemme MC, Östling M. Efficient inkjet printing of graphene. Adv Mater. 2013 Aug
7;25(29):3985‐3992.
[55] Van Osch TH, Perelaer J, de Laat AW, Schubert US. Inkjet printing of narrow conductive tracks on untreated polymeric substrates. Adv Mater. 2008 Jan 18;20(2):343‐345.
[56] Sirringhaus H, Kawase T, Friend RH, et al. High‐resolution inkjet printing of all‐polymer transistor circuits. Science. 2000 Dec
15;290(5499):2123‐2126.
[57] B. Li, P.A. Clark, K.H. Church (Eds.), Robust Direct-Write Dispensing Tool and Solutions for Micro/Meso- Scale Manufacturing and Packaging. ASME 2007 International Manufacturing Science and Engineering Conference; 2007.
[58] Sachs, E.M., J.S. Haggerty, M.J. Cima, and P.A. Williams, Three-dimensional printing techniques. 1993, Google Patents.
[59] Utela B, Storti D, Anderson R, Ganter M. A review of process development steps for new material systems in three dimensional printing (3DP). J Manuf Process 2008;10(2):96e104.
[60] Ge Q, Dunn CK, Qi HJ, Dunn ML. Active origami by 4D printing. Smart Mater Struct 2014;23(9):094007.
[61] Postiglione G, Natale G, Griffini G, Levi M, Turri S. Conductive 3D microstructures by direct 3D printing of polymer/carbon nanotube nanocomposites via liquid deposition modeling. Compos Part A Appl Sci Manuf 2015;76:110e4.
[62] Saari M, Cox B, Richer E, Krueger PS, Cohen AL. Fiber Encapsulation Additive Manufacturing: An Enabling Technology for 3D Printing of Electromechanical Devices and Robotic Components. 3D Print Addit Manuf 2015;2(1):32e9.
[63] Yan, Q., Dong, H., Su, J., Han, J., Song, B., Wei, Q., & Shi, Y. (2018). A review of 3D printing technology for medical applications. Engineering, 4(5), 729-742.
[64] Diegel O, Withell A, de Beer D, Potgieter J, Noble FK (2012) Low-cost 3D printing of controlled porosity ceramic parts. IJAT 6(5):618–626
[65] Halloran JW, Tomeckova V, Gentry S, Das S, Cilino P, Yuan D, Guo R, Rudraraju A, Shao P,Wu T (2011) Photopolymerization of powder suspensions for shaping ceramics. J Eur Ceram Soc 31(14):2613–2619
[66] Wohlers T (2014) Tracking global growth in industrial-scale additive manufacturing. 3D. Print Addit Manuf 1(1):2–3
[67] Liao Y, Li H, Chiu Y (2006) Study of laminated object manufacturing with separately applied heating and pressing. Int J Adv Manuf Technol 27(7-8):703–707
[68] Invernizzi M, Natale G, Levi M, Turri S, Griffini G (2016) UVassisted 3D printing of glass and carbon fiber-reinforced dual-cure polymer composites. Materials 9(7):583
[69] Misra AK, Grady JE, Carter R (2015) Additive manufacturing of aerospace propulsion components.
[70] A world first: additively manufactured titanium components now onboard the Airbus A350 XWB. https://www.etmm-online.com/a-world-first-additively-manufactured-titanium-componentsnow-onboard-the-airbus-a350-xwb-a-486310/. Accessed 25/02/2019
[71] Fit to print: new plant will assemble world’s first passenger jet engine with 3d printed fuel nozzles, Next-Gen Materials. https://www.ge.com/reports/post/80701924024/fit-to-print/. Accessed 25/02/2019.
[72] Meaney J, Goyen M. Recent advances in contrast-enhanced magnetic resonance angiography. Eur Radiol 2007;17:B2e6.
[73] Hollister SJ. Porous scaffold design for tissue engineering. Nat Mater 2005;4(7):518e24.
[74] Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol 2014;32(8):773e85.
[75] Leigh SJ, Bradley RJ, Purssell CP, Billson DR, Hutchins DA. A simple, low-cost conductive composite material for 3D printing of electronic sensors. PloS one
2012;7(11):e49365.
[76] Farahani RD, Dalir H, Le Borgne V, Gautier LA, El Khakani MA, L_evesque M, Therriault D. Direct-write fabrication of freestanding nanocomposite strain sensors. Nanotechnology 2012;23(8):085502.
[77] Mannoor MS, Jiang Z, James T, Kong YL, Malatesta KA, Soboyejo WO, Verma N, Gracias DH, McAlpine MC. 3D printed bionic ears. Nano Lett 2013;13(6):2634e9.
[78] L.J. Zhang, T.J. Webster, Nanotechnology and nanomaterials: Promises for improved tissue regeneration, Nano Today 4(1) (2009) 66-80.
[79] J. R. Xavier, T. Thakur, P. Desai, M. K. Jaiswal, N. Sears, E. Cosgriff-Hernandez, R. Kaunas, A. K. Gaharwar, ACS Nano 2015,9, 3109.
[80] Zhang, L., Webster, Thomas J. Nanotechnology and nanomaterials: Promises for improved tissue regeneration. Nano today 4, 2009.
[81] N. Mansouri, S. Bagheri, The influence of topography on tissue engineering perspective, Mater. Sci. Eng. C Mater. Biol. Appl. 61 (2016) 906–921.
[82] D. Singh, D. Singh, S. Zo, S.S. Han, Nano-biomimetics for nano/micro tissue regeneration, J. Biomed. Nanotechnol. 10 (2014) 3141–3161.
[83] E. A. Guzzi, M. W. Tibbitt, Adv. Mater. 2019, 1901994.
[84] D. Chimene, K. K. Lennox, R. R. Kaunas, A. K. Gaharwar, Ann. Biomed. Eng. 2016, 44, 2090
[85] C. Cha, S.R. Shin, N. Annabi, M.R. Dokmeci, A. Khademhosseini, Carbon-based nanomaterials:multifunctional materials for biomedical engineering, ACS Nano 7(4) (2013) 2891-2897.
[86] A.E. Jakus, E.B. Secor, A.L. Rutz, S.W. Jordan, M.C. Hersam, R.N. Shah, Three-dimensional printing of high-content graphene scaffolds for electronic and biomedical applications, ACS Nano 9(4) (2015) 4636-4648.
[87] M. Jahanshahi, A.D. Kiadehi, Fabrication, purification and characterization of carbon nanotubes: arc-discharge in liquid media (ADLM), Synth. Appl. Carbon Nanotub. Their Compos. (2013),
[88] C. Cha, S. R. Shin, N. Annabi, M. R. Dokmeci, A. Khademhosseini, ACS Nano 2013, 7, 2891.
[89] S.J. Lee, W. Zhu, M. Nowicki, G. Lee, D.N. Heo, J. Kim, Y.Y. Zuo, L.G. Zhang, 3D printing nano conductive multi-walled carbon nanotube scaffolds for nerve regeneration, J Neural Eng 15(1) (2018) 016018.
[90] S.I. Roohani-Esfahani, H. Zreiqat, Nanoparticles: a promising new therapeutic platform for bone regeneration, Nanomedicine (Lond) 12(5) (2017) 419-422.
[91] C. Wang, Q. Zhao, M. Wang, Cryogenic 3D printing for producing hierarchical porous and rhBMP-2-loaded Ca-P/PLLA nanocomposite scaffolds for bone tissue engineering, Biofabrication 9 (2017), 025031.
[92] N.J. Castro, J. O'Brien, L.G. Zhang, Integrating biologically inspired nanomaterials and table-topstereolithography for 3D printed biomimetic osteochondral scaffolds, Nanoscale 7(33) (2015) 14010-14022.
[93] X. Yang, et al., The stimulatory effect of silica nanoparticles on osteogenic differentiation of human mesenchymal stem cells, Biomed. Mater. 12 (2016), 015001.
[94] J. Li, J.J. Li, J. Zhang, X. Wang, N. Kawazoe, G. Chen, Gold nanoparticle size and shape influence on osteogenesis of mesenchymal stem cells, Nanoscale 8(15) (2016) 7992-8007.
[95] S. Vial, R. L. Reis and J. M. Oliveira, Curr. Opin. Solid State Mater. Sci., 2017, 21, 92–112.
[96] S. Jina´Lee, J. Mina´Seok, J. Heea´Lee, W. Dooa´Kim, I. Keuna´Kwon and S. Aa´Park, Nanoscale, 2018, 10, 15447–15453.
[97] Medeiros, S.F.; Santos, A.M.; Fessi, H.; Elaissari, A. Stimuli-responsive magnetic particles for biomedical applications. Int. J. Pharm. 2011, 403, 139–161.
[98] Fathi-Achachelouei, M.; Knopf-Marques, H.; Ribeiro da Silva, C.E.; Barthès, J.; Bat, E.; Tezcaner, A.; Vrana, N.E. Use ofnanoparticles in tissue engineering and regenerative medicine. Front. Bioeng. Biotechnol. 2019, 7, 113.
[99] Vial, S.; Reis, R.L.; Oliveira, J.M. Recent advances using gold nanoparticles as a promising multimodal tool for tissue engineering and regenerative medicine. Curr. Opin. Solid State Mater. Sci. 2017, 21, 92–112.
[100] Prabhu, S.; Poulose, E.K. Silver nanoparticles: Mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int. Nano Lett. 2012, 2, 32.
